The Reaction of Pyridazine 1-Oxide with Grignard Reagent
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The Solvent Effects on Grignard Reaction
This research focuses on the effects of water in a solvent on a synthetic process of a Grignard reagent which is common in organic synthesis and triggered an accident in Japan. For the measurement, a hermetically sealed apparatus was prepared to fit a small-scaled reaction calorimeter. The experimental results revealed that the induction period appeared as the water content in the solvent incre...
متن کاملHow to prepare a chiral Grignard reagent: a theoretical proposal.
It is shown that two competitive pathways (T2 vs T4) exist for Grignard reagent formation. While the nonradical pathway T2 leads to retention of the configuration, the radical pathway T4 gives racemization. Our calculations suggest the way that T2 can be enhanced, which should be of significance to prompt new synthesis approaches for the preparation of chiral Grignard reagents.
متن کاملReaction of sodium aminohippurate with Folin's reagent.
ITIS WELL RECOGNIZED that the Folin phenol method (1) for the determination of protein is not specific. This method was in fact originally standardized with protein or tyrosine, and the Folin phenol reagent was shown to react with numerous mono-, di-, and trihydroxyphenols in addition to other substances (s). Although most of these substances are not present in sufficient amounts to interfere w...
متن کاملRadical isomerization during Grignard reagent formation. A quantitative treatment.
( l ) (a) Walborsky, H.M.; Young, A. E. J. Am. Chem. Soc. 1961,83, 2595. (b) Walborsky, H. M.; Young, A. E. J. Am. Chem. Soc. 1964, 86,3288. (c) Wafborsky, H. M.; Aronoff, M. S. "/. Organomet. Chem. 1973, 5i,,31. (d) Walborsky, H. M.; Banks, R. B. Bul / . Soc. Chim. Belg.1980,89,849. (2) Ruchardt , C. ; Trautwein, H. Chem. Ber. 1962,95, 1197. (3) Patel , D. J. ;Hami l ton, C. L. ;Roberts, J.D. ...
متن کاملThe reaction of Koshland's protein reagent with tryptophan.
A valuable reagent for labelling the tryptophan residue in proteins has been described by Koshland and co-workers. 2, 3 The reagent, 2-hydroxy-5-nitrobenzyl bromide, HNBB,4 is both highly selective for the tryptophan residue under mild reaction conditions and introduces the environmentally sensitive E-nitrophenol chromophore (Amax (acidic) 320 rnp; Xmax (basic) 409 rnw) into the protein. It was...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1969
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.17.2502